
In a nutshell
- The WID®-easy test is an epigenetic test for the early detection of uterine cancer for women who suffer from abnormal uterine bleeding during or after menopause.
- The test saves many women with abnormal bleeding from having to undergo surgery to diagnose whether cancer is the cause of the bleeding.
- The test only requires a swab from the vagina.
Notice:
All scientific and medical information on this page comes from publicly available sources, which are indicated in the text. Sola Diagnostics does not provide medical advice and makes no recommendations for action.
Uterine cancer

Uterine cancer
Uterine cancer is the most common cancer of the female reproductive organs (www.gesund.bund.de).
It predominantly affects women after menopause; only about five percent are younger than 40. Until menopause, the lining of the uterus (endometrium) renews itself every month. Periodically, the upper layers are shed and expelled with menstruation. Changes to the uterus lining in which individual cells turn into cancer cells are more common during and after menopause.
In Western countries, uterine body cancer is twice as common as cervical cancer.
In Germany, Austria and Switzerland, almost 15,000 women are diagnosed with cancer of the uterine corpus (www.ecis.jrc.ec.europa.eu) every year.
Risk factors
A major risk factor is prolonged, elevated estrogen concentration in the female body. Women with menstrual irregularities, late menopause, childlessness, or certain hormone replacement therapies have an increased risk of developing this type of cancer.
Lifestyle diseases such as obesity, high blood pressure or type 2 diabetes mellitus can also increase the risk of tumors. It is known that obesity increases estrogen production. Whether there is a risk from phytoestrogens (estrogen-like substances in foods) has not yet been clarified. However, hormone therapy with estrogen alone certainly increases the risk (www.gesund.bund.de).
Symptoms
Cancer at an early stage is rarely detected during routine examinations. However, the disease becomes apparent relatively early with sudden, abnormal bleeding. Post-menopausal bleeding, irregular bleeding and flesh-colored discharge are in principle always suspicious and should be examined.
Abnormal uterine bleeding during or after menopause may be an indication of uterine cancer.
Diagnostics
First, your gynecologist will ask you about your general health (medical history) and perform a gynecological exam. A sonography probe is then inserted into the vagina to assess the lining of the uterus (endometrium).
If the endometrium is thicker than expected, a hysteroscopy and biopsy of the uterus (“abrasion” or “curettage”) are performed to clarify the suspicion of uterine cancer. Biopsy procedures are surgical and are relatively complex. They are performed under general anesthesia and carry the risk of bleeding, infection, or other complications of surgical procedures, such as injury or perforation of the uterus or even anesthetic incidents.
First, the doctor looks inside the uterus with a small camera (hysteroscope). They will check for visible changes to the endometrium. Following hysteroscopy, a biopsy of the uterus lining is taken and sent to the laboratory for examination. The biopsy may be taken from an area of the uterus lining that has the characteristics of cancer (targeted biopsy) or be scraped from the top layer of the womb lining (curettage).

Comparison of diagnostic methods
During hysteroscopy and curettage, the cervix is surgically dilated to allow instruments to be inserted into the uterine cavity. With the WID®-easy test, on the other hand, a swab from the upper vaginal area is sufficient.
90 % less curettages

Transvaginal sonography
Out of 40 women who suffer from abnormal bleeding during or after menopause, about one woman will have uterine cancer. Nevertheless, the sonography will sound the alarm in 20 of these women (reddish background), and the women have to undergo curettage. Of these 20 women, 19 women do not have cancer.

The WID®-easy test
In the same situation, the WID®-easy test will have a positive result in only two women, so only two women will have to undergo a curettage (reddish background). Of these two women, only one does not have cancer.
Compared to transvaginal sonography, significantly fewer women who do not have cancer receive a false positive test result (“false alarm”) with the WID®-easy test. As a result, significantly fewer curettages need to be performed. With sonography, there are twenty women, and with the WID®-easy test, there are only 2 women who need a curettage. That’s a 90% reduction.
In a direct comparison between the WID®-easy test and the ultrasound method, it was shown that with the WID®-easy test, for every woman with cancer, there is only one woman without cancer who has to undergo a curettage (positive predictive value [PPV] of 50 %), while in sonography, for every woman with cancer, there are 19 women without cancer who has to undergo a curettage (positive predictive value [PPV] of 5 %). Thus, the WID®-easy test reduces the number of necessary surgical interventions in women who do not have cancer by as much as 95%.
(Source: Evans et al., The Lancet Oncology, 2023)
How is the WID®-easy test performed?
The test is very simple to perform: your doctor will take a swab from your vagina, very similar to the swab that is taken during your cervical cancer screening (“PAP smear”).
The sample is analyzed in the laboratory by PCR (similar to a Covid test) and after a few days, you can discuss the result with your doctor.
(Quelle: www.eutops.institute)
Are you interested in the WID®-easy test?
Where can you get the WID®-easy test?
Your doctor will collect the sample for the WID®-easy test. The result of the test and the conclusions and consequences to be drawn from it will be discussed with you.
If you are interested in the WID®-easy test, please discuss this with your doctor. They will be able to discuss with you whether the test is suitable and useful for you.
In which countries is the WID®-easy test available?
From 2024, the WID®-easy test will be offered by diagnostic laboratories in Austria and Switzerland. Ask your doctor if they can obtain services from one of these laboratories.
What does the WID®-easy test cost?
Discuss the cost of the test with your doctor. The costs will include the following:
- Costs for the diagnostic laboratory to perform the test and report to your doctor. This also includes the license fee of Sola Diagnostics GmbH on a pro-rata basis.
- Your doctor’s costs for sample collection and consultation.
The costs that you as a patient have to bear also depend on the country in which you or your physician and the laboratory performing the test are located, as well as on your insurance status.
For those who want to know the details
Sensitivity, specificity and the predictive value (PPV/NPV)
The accuracy of the WID®-easy test
%
Specificity
%
Sensitivity
%
Positive Predictive Value (PPV)
%
Negative Predictive Value (NPV)
The direct comparison to sonography
The WID®-easy test is characterized by extremely high values for sensitivity (90.9%), specificity (97.3%) and negative predictive value (99.7%).
Vor allem aber ist der positive Vorhersagewert mit 50 % zehnmal höher als der der Sonographie, deren PPV nur 5 % beträgt (Evans et al., The Lancet Oncology, 2023).

How does the WID®-easy test work?
The WID®-easy test is a so-called epigenetic DNA methylation test.
DNA” is the term used to describe the human genetic material that parents pass on to their children. It consists of various long filaments (“chromosomes”) that are tightly coiled in every cell of the body. DNA plays an important role in controlling the biological processes of the cell. Different regions of the DNA have different functions.
The so-called “DNA methylation” is a process that controls the activity of the different DNA regions. You can think of methylation as little marks on DNA.
This makes it possible for different processes to take place in different cells and for the cells to take on different tasks. DNA methylation is therefore not a genetic mutation but merely a modification of the DNA.

The principle of the WID®-easy test
The WID®-easy test measures the methylation status of DNA regions known to be differentially methylated in uterine cancer.
Environmental influence on genes
Unlike the static DNA sequence, epigenetic DNA methylation patterns are subject to change and can also be influenced by the environment and personal lifestyle.